The Negative Sense RNA Hantavirus – A Threat to the Modern World
Hantaviruses are rodent-borne zoonotic pathogenic viruses that produce two major clinical syndromes in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). These are negative sense RNA viruses. Each hantavirus type has a single predominant natural reservoir and is transmitted through aerosolized rodent excreta or rodent bites. Case fatality rates for HFRS can reach up to 15% and for HPS can exceed 40%. Very recently, the occurrence of hantavirus has been seen in China in March, 2020. This review summarizes the current knowledge on virology, epidemiology, clinical manifestation, laboratory diagnostics, treatment, and prevention of hantaviruses and hantaviral infections.
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