Tubulointerstitial nephritis and uveitis syndrome: A case series

Authors

  • Said Kaddouri Ibn Sina Military hospital, Marrakesh, Morocco
  • Hassan Qacif Ibn Sina Military Hospital, Marrakesh, Morocco
  • Zakaria Chahbi Ibn Sina Military Hospital, Marrakesh, Morocco
  • Zemraoui Nadir Department of Nephrology,
  • Mohamed Zyani Ibn Sina Military Hospital, Marrakesh, Morocco

DOI:

https://doi.org/10.21276/apjhs.2017.4.4.3

Abstract

The tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) affects adolescent females preferentially, and it is typically
characterized by the association of tubulointerstitial nephritis and anterior bilateral uveitis. However, it may have different atypical
presentations. It can be seen in male, in adults, without renal insufficiency, or with a posterior uveitis. We report three cases of
atypical TINU syndrome. We reported two out of three adult patients (16, 60, and 62 years of age), two of whom were female and
one male. The first patient had a panuvéitis of the left eye and a posterior uveitis of the right eye. The second patient presented
bilateral panuveitis with retinal vasculitis. The third patient had a bilateral anterior uveitis recurrent. The three patients had
proteinuria, glucosuria, aseptic leukocyturia without renal insufficiency. Renal biopsy showed tubulointerstitial nephritis with
no sign of vasculitis or glomerular involvement. The etiological investigation did not find any cause (infection, medication, and
systemic illness). The patients received a local and general corticosteroid therapy associated in one case with methotrexate, which
has resulted in rapid improvement for all three patients. This clinical case report highlights some important features of TINU
syndrome, including the increasing incidence of disease in male and adult patients, the possibility of a posterior involvement of
uveitis, and clinical presentation without kidney failure. Extensive studies are needed to elucidate the cause and pathogenesis of
this syndrome for better management.

 

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Author Biographies

Said Kaddouri, Ibn Sina Military hospital, Marrakesh, Morocco

 Department of Internal Medicine,

Hassan Qacif, Ibn Sina Military Hospital, Marrakesh, Morocco

Department of Internal Medicine, 

Zakaria Chahbi, Ibn Sina Military Hospital, Marrakesh, Morocco

Department of Internal Medicine,

Zemraoui Nadir, Department of Nephrology,

Ibn Sina Military Hospital, Marrakesh, Morocco

Mohamed Zyani, Ibn Sina Military Hospital, Marrakesh, Morocco

Department of Internal Medicine, 

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Published

2017-12-30

How to Cite

Said Kaddouri, Hassan Qacif, Zakaria Chahbi, Zemraoui Nadir, & Mohamed Zyani. (2017). Tubulointerstitial nephritis and uveitis syndrome: A case series. Asian Pacific Journal of Health Sciences, 4(4), 9–11. https://doi.org/10.21276/apjhs.2017.4.4.3