Characterization of Impurities in Reverse Transcriptase Inhibitors by Profiling Techniques

Authors

  • Ashwini V. Shelke Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India, Department of Pharmaceutical Chemistry, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India
  • Tushar N. Lokhande Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India
  • Vaishali Pardeshi Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India
  • Kavita Daware Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India
  • Shweta Jadhav Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India
  • Anil Jadhav Department of Pharmaceutical Chemistry, Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Nashik, Maharashtra, India

DOI:

https://doi.org/10.21276/apjhs.2022.9.4S.06

Keywords:

Anti-retroviral drugs, HIV, Impurity profiling, International council for harmonization guidelines, Reverse transcriptase inhibitors, HIV

Abstract

There has been ever growing activity in impurities existing in pharmaceutical products as well as bulk drugs. According to a range of regulatory authorities, no longer solely purity profiles, however additionally impurity profiles, are now required. The technique facts for an individual impurity’s organic safety are recognized as impurity profiling. The many developments in analytical viewpoints of impurity profiling of anti-retroviral (ARV) medicines and products used to deal with human immunodeficiency virus (HIV) infections are described in this review. ARVs work using inhibiting unique ranges of the viral contamination cycle to produce therapeutic benefits. Thus, drug classes are stratified as nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NTRTIs), non-NRTIs (NNRTIs), integrase strand transfer inhibitors, CCR5 antagonists, viral fusion inhibitors, and protease inhibitors (PIs). In this overview predominant focal point given on class that is reverse transcriptase inhibitors (RTIs). The wide variety of papers dealing with ARV drug impurity profiling is developing at an alarming pace. The cutting-edge overview article, which is based primarily on publications posted in the closing 15 years, tries to provide vast data concerning RTIs drug impurity profiling. RTIs which are labeled into two sub-categories, that is, NRTIs and NNRTIs. NRTIs pressure the HIV virus to use erroneous variations of building block, so contaminated cells cannot make more HIV and NNRTIs these are additionally referred to as “non-nukes.” NNRTIs bind to a precise protein so the HIV virus cannot make copies of itself. The investigatory overview might also furnish the complete important points to the researchers who are working in the region of impurity profiling of RTIs. To the most tremendous of our information, no overview until date noted to center of attention on impurity profiling of RTIs.

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Published

2022-06-25

How to Cite

Ashwini V. Shelke, Tushar N. Lokhande, Vaishali Pardeshi, Kavita Daware, Shweta Jadhav, & Anil Jadhav. (2022). Characterization of Impurities in Reverse Transcriptase Inhibitors by Profiling Techniques. Asian Pacific Journal of Health Sciences, 9(4), 18–26. https://doi.org/10.21276/apjhs.2022.9.4S.06