A study on C-reactive protein as an early marker of vasococclusive crisis in sickle disorders

Authors

  • Anindya Sasmal ICARE Institute of Medical Sciences and Research,Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India
  • Kausik Goswami ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India
  • Sheela Kandulna (Goswami) ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India
  • Prakash Chandra Panda Veer Surendra Sai Institute of Medical Sciences and Research, PO- Burla, Dist. Sambalpur, Odisha 768017, India
  • I R Agrawalla Veer Surendra Sai Institute of Medical Sciences and Research, PO- Burla, Dist. Sambalpur, Odisha 768017, India
  • Sukanta Sen ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.4.9

Keywords:

Sickle cell disease, vaso-occlusive crisis, C-reactive protein, marker, sickling test, hemoglobin electrophoresis, high performance liquid chromatography

Abstract

Background: Sickle cell disease (SCD) patients often seek care in the Emergency Department (ED) due to vaso-occlusive crisis (VOC), the most common complication of SCD. Currently, no diagnostic test can determine if a SCD patient is having an acute VOC. Methodology: Irrespective of the clinical diagnosis and type of sickle cell crises the confirmation of haemoglobin pattern in sickle cell disease patients and healthy subjects were done by sickling test, hemoglobin electrophoresis or high performance liquid chromatography. Results: Irrespective of age and sex, most common variety of vaso-occlusive crisis was bony crisis including hand foot syndrome. About 91.2% patients demonstrated CRP positivity during the early phase of vaso-occlusive crisis. Subsequently the CRP positivity rate declined in the mid phase (28%) and late phase (2.4%) of vaso-occlusive crisis reflecting response to therapy. There is a significant difference of CRP status between non vasoocclusive and vaso–occlusive crisis of sickle cell disease patients. About 96.3% patients of non vaso-occlusive crisis became CRP negative during their whole course of their crisis. Conclusion: Analysis of large number of cases with sickle cell vaso-occlusive crisis with quantitative serial measurement of CRP level is needed for better evaluation of patients during prodromal phase for effective and better management of these patients.

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Author Biographies

Anindya Sasmal, ICARE Institute of Medical Sciences and Research,Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India

Assistant Professor, Department of Radiodiagnosis

Kausik Goswami, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India

Assistant Professor, Department of Pediatrics

Sheela Kandulna (Goswami), ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India

Assistant Professor, Department of Pediatrics

Prakash Chandra Panda, Veer Surendra Sai Institute of Medical Sciences and Research, PO- Burla, Dist. Sambalpur, Odisha 768017, India

Associate Professor, Department of Paediatrics

I R Agrawalla, Veer Surendra Sai Institute of Medical Sciences and Research, PO- Burla, Dist. Sambalpur, Odisha 768017, India

Professor, Department of Paediatrics

Sukanta Sen, ICARE Institute of Medical Sciences and Research, Banbishnupur, Purba Medinipur, Haldia, West Bengal 721645, India

Professor, Department of Pharmacology

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Published

2018-12-30

How to Cite

Anindya Sasmal, Kausik Goswami, Sheela Kandulna (Goswami), Prakash Chandra Panda, I R Agrawalla, & Sukanta Sen. (2018). A study on C-reactive protein as an early marker of vasococclusive crisis in sickle disorders. Asian Pacific Journal of Health Sciences, 5(4), 43–53. https://doi.org/10.21276/apjhs.2018.5.4.9

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