Proniosome-Based Transdermal Drug Delivery of Resveratrol
Keywords:Permeation, Proniosomes, Resveratrol, Transdermal drug delivery
Vesicular systems have been receiving a lot of interest as a carrier for advanced drug delivery. The present investigation aimed at the development and characterization of proniosome based transdermal delivery of resveratrol. The proniosomal structure was a liquid crystalline-compact niosomes hybrid which could be converted into niosomes upon hydration by skin itself. To optimize the formulation, various proniosomes composed of various ratios of sorbitan fatty acid esters, polysorbates, cholesterol, and lecithin were prepared by the coacervation-phase separation method. From each of the prepared proniosomes, the entrapment efficiency with span 60 was found to be the highest. The effects of cholesterol, phospholipids, and solvents were also assessed. Optimized formulation was characterized for entrapment efficiency, scanning electron microscope, transmission electron microscope, in vitro release study, vesicle size, and stability studies at 4°C and room temperature. Thus, proniosome was found to be a promising carrier system for resveratrol because of ease of preparation and better bioavailability.
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Copyright (c) 2023 Bhawana Sharma, Amul Mishra, Piush Sharma, Shiv Garg, Abhishek Dwivedi, Savita Rathor
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