The role of prostaglandin E2 in children with lower urinary tract dysfunction

Abstract

Objectives: The objective of the study is to examine the effect of prostaglandin E2 (PGE2) in the etiology of children with lower urinary tract dysfunction (LUTD), we formed this prospective study. The role of PGE2 in children with LUTD has not been reported yet. Materials and Methods: Between October 2010 and April 2012, a total of 91 children between 5 and 15 years age enrolled in this study. A total of 11 children were excluded from the study for active urinary tract infection. About 48 children from a nursery and a primary school were chosen as a control group. Nearly 32 of the children had LUTD. Results: The median PGE2 was not statistically significant different between LUTD and control group (P = 0.93), but the PGE2 level was higher in control group. Although there was no statistically significant difference between genders and between the patients with overactive bladder (OAB) symptoms, postvoid residual (PVR), enuresis, and opposites, or according to voiding patterns; the PGE2 level was higher in the patients with OAB symptoms, enuresis, and tower voiding pattern. On the other hand, the PGE2 level was lower in the patients with PVR. Conclusions: PGE2 may not be an etiological factor in children with LUTD. Higher PGE2 levels in control group and lower PGE2 levels in patients with PVR offers further examinations to understand the PGE2 effect.