Solubility enhancement of fenofibrate by modified locust bean gum using solid dispersion techniques

Authors

  • ```````````````````````````````````````````````````````````````````````````````````Deepak Choudhary```` ``````````````````````````````````Mohanlal Sukhadia University, Udaipur, Rajasthan, India
  • ``````````````````````````` Sameer Gangal`````````````````````````` Jodhpur National University, Jodhpur, Rajasthan, India,
  • `Dinesh Puri` Ghaziabad, Uttar Pradesh, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.2.41

Keywords:

Fenofibrate, kneading, modified locust bean gum, solid dispersion, solvent evaporation

Abstract

Introduction: Modern techniques, such as high-throughput screening or combinatorial chemistry, facilitate the speedy identification of new, highly potent chemical entities. Very often new compounds exhibit higher molecular weights and lower water solubility compared to drugs already on the market. Fenofibrate is poorly water-soluble (BCS class II) drug. Aim and Objectives: The aim of present study was to develop an alternative carrier to reduce the production cost and toxic effects and enhance the solubility of fenofibrate. Results: The solid dispersions were prepared using modified locust bean gum using kneading and solvent evaporation method that increased in apparent solubility and the dissolution rate of fenofibrate.

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Author Biographies

```````````````````````````````````````````````````````````````````````````````````Deepak Choudhary````, ``````````````````````````````````Mohanlal Sukhadia University, Udaipur, Rajasthan, India

Department of Pharmaceutical Sciences, `

``````````````````````````` Sameer Gangal``````````````````````````, Jodhpur National University, Jodhpur, Rajasthan, India,

Faculty of Pharmaceutical Sciences,

`Dinesh Puri`, Ghaziabad, Uttar Pradesh, India

I.T.S College of Pharmacy, 

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Published

2018-06-30

How to Cite

```````````````````````````````````````````````````````````````````````````````````Deepak Choudhary````, ``````````````````````````` Sameer Gangal``````````````````````````, & `Dinesh Puri`. (2018). Solubility enhancement of fenofibrate by modified locust bean gum using solid dispersion techniques. Asian Pacific Journal of Health Sciences, 5(2), 224–230. https://doi.org/10.21276/apjhs.2018.5.2.41

Issue

Vol. 5 No. 2 (2018): Vol 5 | Issue 2 | April - June 2018

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.