Cutaneous amyloidosis masquerading as cutaneous metastasis: a rare report with unusual presentation

Abstract

Aim: To report a case of cutaneous amyloidosis that mimicked metastatic malignancy clinically. Methods and results: A 65-year-old-male, presented with nodular cutaneous swellings all over the body extending from scalp to the extremities and trunk with a lesion on tongue. History of tobacco chewing and smoking was present since last 20 years. Fine needle aspiration cytology (FNAC) of the skin nodules and imprint cytology of the tongue lesion showed abundant extracellular material resembling tumor necrosis, with interspersed squamous cells. Positive clinical findings and equivocal FNAC findings favoured malignancy. However, histopathological findings of skin nodules and tongue lesion were consistent with cutaneous amyloidosis.Conclusions: Cutaneous amyloidosis mimicking malignancy is rarely reported earlier in literature. This report emphasizes that cutaneous amyloidosis should always be considered in cases of multiple skin lesions, suspected of malignancy with skin metastasis.