The effects of oral vitamin A (retinol) on chemically–induced corneal ulcer in guinea pigs
Keywords:Alkali injury, corneal ulcer, retinol, wound healing
The effects of the healing propensity of vitamin A (retinol), a vital micro-nutrient were studied on chemically– induced corneal ulcers in guinea pigs. Corneal regeneration following alkaline injury was studied by fluorescent dye staining of the cornea under cobalt blue light, while digital photographs were taken every 6 hours. Results showed that administration of vitamin A syrup reversed the epithelial damage, produced accelerated wound healing, restored the eyelid status, light-reflex and corneal lustre, abolished corneal infiltrates and lacrimation in the treated group while the positive control (untreated) group had slow healing process as the ulceration continued unhindered. It is, therefore, concluded that vitamin A administered systemically facilitates the rate of epithelial regeneration in the cornea following traumatic injury or damage.
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