Baclofen-induced toxic encephalopathy in end-stage renal disease: should we be more careful?
Keywords:Baclofen, Encephalopathy, Dialysis, End-stage renal disease
Baclofen is a highly used centrally acting GABA agonist that continues to be an effective therapy for symptomatic relief of skeletal muscle spasm and spasticity in traumatic spinal cord lesions, multiple sclerosis, cerebral palsy, stroke and chronic hiccups and has recently become popular as recreational drug. The renally dependent excretion determines the circulating concentrations and guides effective dosing to decrease adverse reactions. Caution should be considered in administering baclofen to patients with decreased renal function. We present a patient with end stage renal disease on hemodialysis with recent baclofen ingestion who presented with toxic encephalopathy that was resolved with additional dialysis sessions.
How to Cite
Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.