Formulation and evaluation of effervescent floating tablet of famotidine with natural polymer chitosan

Authors

  • Harsharan Pal Singh Noida Institute of Engineering & Technology, Greater Noida, UttarPradesh, India
  • Ashmeet Kaur Pushp Vihar, New Delhi, India
  • Ishpreet Kaur Pushp Vihar, New Delhi, India

DOI:

https://doi.org/10.21276/apjhs.2014.1.4.37

Keywords:

Famotidine, Chitosan, Effervescent floating tablet, Direct compression, Buoyancy studies

Abstract

A Novel floating controlled release drug delivery system of famotidine was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. The present work investigates the approach using two different polymers HPMC K100 M and natural polymer Chitosan . A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, citric acid and hydrocolloids, like hydroxyl propyl methylcellulose (HPMC), MCC, PvP k30 and chitosan. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in vitro release, buoyancy and buoyancy lag-time. Famotidine effervescent floating tablets were developed by direct compression technique. F5 formulation showed maximum floating time of 17 hours and gave controlled and maximum drug release of over 17h.Therefore the formulation F5 found to be optimized, to achieve the goal of formulation and evaluation of effervescent floating tablet of famotidine. The effect of citric acid on a floating properties and drug release profile was also investigated. A combination of sodium bicarbonate and citric acid was found to achieve required in-vitro buoyancy. 

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Author Biographies

Harsharan Pal Singh, Noida Institute of Engineering & Technology, Greater Noida, UttarPradesh, India

Department of Pharmaceutical Technology, 

Ashmeet Kaur, Pushp Vihar, New Delhi, India

Delhi Institute of Pharmaceutical Sciences & Research, 

Ishpreet Kaur, Pushp Vihar, New Delhi, India

Delhi Institute of Pharmaceutical Sciences & Research, 

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Published

2014-12-30

How to Cite

Harsharan Pal Singh, Ashmeet Kaur, & Ishpreet Kaur. (2014). Formulation and evaluation of effervescent floating tablet of famotidine with natural polymer chitosan. Asian Pacific Journal of Health Sciences, 1(4), 517–523. https://doi.org/10.21276/apjhs.2014.1.4.37