Ofloxacin induced steven johnson syndrome- case report

Authors

  • Apollo James Nandha College of Pharmacy, Erode, Tamilnadu, India
  • Ammu A Nandha College of Pharmacy, Erode, Tamilnadu, India
  • Jasmin Elizabeth Thomas Nandha College of Pharmacy, Erode, Tamilnadu, India
  • Merin Joseph Nandha College of Pharmacy, Erode, Tamilnadu, India
  • T.R. Ashok kumar Nandha College of Pharmacy, Erode, Tamilnadu, India
  • T.Sivakumar Nandha College of Pharmacy, Erode, Tamilnadu, India

DOI:

https://doi.org/10.21276/apjhs.2015.2.2.3

Keywords:

Ofloxacin, Toxic Epidermal Necrosis, Steven Johnson syndrome

Abstract

Steven Johnson syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) is a life threatening immune complex mediated hypersensitivity reaction which mainly involves skin and mucous membrane. SJS is generally induced by the drugs. The manifestations include blisters on skin, facial swelling, and hyper pigmentation. Here, a 20 year old Indian male received 400mg of ofloxacin over 3 days period for bacterial infection and experienced a severe skin reaction which was diagnosed as toxic epidermal necrolysis. Fluoroquinolones have rarely been implicated in cases of toxic epidermal necrosis. There are few case reports of other fluoroquinolones that have been associated with toxic epidermal necrolysis. We hope that this case report create awareness to the health care professionals that ofloxacin will cause toxic epidermal necrolysis.

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Author Biographies

Apollo James, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice, 

Ammu A, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice, 

Jasmin Elizabeth Thomas, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice,

Merin Joseph, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice,

T.R. Ashok kumar, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice, 

T.Sivakumar, Nandha College of Pharmacy, Erode, Tamilnadu, India

Department of Pharmacy Practice, 

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Published

2015-06-30

How to Cite

Apollo James, Ammu A, Jasmin Elizabeth Thomas, Merin Joseph, T.R. Ashok kumar, & T.Sivakumar. (2015). Ofloxacin induced steven johnson syndrome- case report . Asian Pacific Journal of Health Sciences, 2(2), 10–11. https://doi.org/10.21276/apjhs.2015.2.2.3

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