Formulation and evaluation of sustained release tablet of cefixime using biopolymer of Phaseolus vulgaris
Keywords:biopolymer, matrix, phaselous vulgaris, sustained release tablet
A need for prolonged and better control of drug administration has increase demand of natural polymer. Recently biopolymer was used to control the drug release rate from the formulation polymer are being used as main incipient. Biopolymer have advantage that they chemically inert, nontoxic, cost effective , ecofriendly, biodegerdable ,biocompatible and easily accepted by regulatory authority as compared to synthetic conterpart. The aim of present study was to develop sustained release matrix tablets of cefixime by using novel isolated biopolymer as a release modifier, obtained from dried seed of been (Phaselous vulgaris).The biopolymer was extracted by non solvent addition method and characterized their physiochemical ,phytochemical and micromeritic property. The advantage of sustain release matrix tablet that they maintain the steady state level of drug in the systemic circulation. The sustained release tablet of cefexime were prepared through wet granulation methods by using different ratios (1:1,1:2,1:3,1:4. and 1:5) of drug and biopolymer. Further the tablet were evaluated for its weight variation, friability, hardness, drug content and in vitro dissolution study. The result obtained that the matrix tablet prepared by using natural polymer can be obtained more than 12 hour and the drug release vary with concentration of polymer in matrix tablet, the above study was found to under limit as pharmacopoeial standard. So the research from the study shows that the biomaterial obtained from the black seed (phaselous vulgaris) serves as a better release modifier in the development of sustained release tablet. So been biopolymer can be used as a better alternative excipients for the development novel drug delivery system.
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