Synthesis and Assessment of Biological Activity of Quinazolinone-4(3H)-one Derivatives as Potential Anticancer Agents

Authors

  • Baljeet Singh Research Scholar, IKG Punjab Technical University, Kapurthala, Punjab, India
  • Shailesh Sharma Department of Pharmaceutical Sciences, ASBASJSM College of Pharmacy, Bela, Punjab, India
  • Manish Sinha Scientific Officer, Government Drug Testing Laboratory, Department of AYUSH, Gwalior, Madhya Pradesh, India
  • S. Sagar Scientist, Skanda Life Sciences Pvt Ltd, R and D Center, Bengaluru, Karnataka, India

Keywords:

Anticancer agents, Breast cancer, cell lines, MCF-7, Quinazolinone-4(3H)-one

Abstract

One of the foremost causes of death around world is cancer. Hence, there is a continuous research going on to find newer anticancer agents with least side effect. Quinazolinone is a privileged framework with prominent anticancer activities. A sequence of eight derivatives (5a-5h) of quinazolinone-4(3H)-one was prepared and tested for activity as anticancer agents against MCF-7 cell lines in this study. One of the compounds 5e showed good activity with 63.71% inhibition of cell growth as compared to 86.96% inhibition by standard doxorubicin.

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Published

2021-10-09

How to Cite

Baljeet Singh, Shailesh Sharma, Manish Sinha, & S. Sagar. (2021). Synthesis and Assessment of Biological Activity of Quinazolinone-4(3H)-one Derivatives as Potential Anticancer Agents. Asian Pacific Journal of Health Sciences, 8(4), 214–220. Retrieved from https://www.apjhs.com/index.php/apjhs/article/view/1624

Issue

Vol. 8 No. 4 (2021): Vol 8 | Issue 4 | October - December 2021

Section

Articles

License

Copyright (c) 2021 Baljeet Singh, Shailesh Sharma, Manish Sinha, S. Sagar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.