Design and development of immediate release tablets of terbutaline sulfate using 32 full factorial statistical design

Authors

  • Prabhjot Singh Bajwa Ch. Devilal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India.
  • Jaya Sharma School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Anurag Bhargava Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Shailesh Sharma Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India
  • Abhimanyu Rai Sharma Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India
  • Binu Raina Ch. Devi Lal College of Pharmacy, Jagadhri, Yamuna Nagar, Haryana, India

DOI:

https://doi.org/10.21276/apjhs.2018.5.1.11

Keywords:

Ac-Di-Sol, Asthma, immediate release tablet, sodium starch glycolate, terbutaline sulfate

Abstract

Aim: Present study was aimed at developing an immediate release tablets (IRT) of Terbutaline sulphate (TS) that can be used forquick relief from asthma attacks.
Method: IRT’s were formulated using Ac-Di-Sol and Sodium starch glycolate as superdisintegrants. There concentrations were optimized using a 32 full-factorial design to produce tablets able to disintegrate within 30 s with minimum friability. Then the tablets were evaluated for physical evaluation and drug release studies.
Results: The optimizedIRT formulation (OIRT1) showed a disintegration time of 31.67 ± 0.577 s and friability value of 0.58 ± 0.021 %. The accelerated stability studies showed no significant changes in physicochemical properties and release behaviour.
Conclusions: It can be concluded from the study that the IRT of TS can be successfully formulated to get a fast release and these tablets can be used to get quick relief from asthma attacks.

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Author Biography

Shailesh Sharma, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, India

Department of Pharmaceutics

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Published

2018-03-30

How to Cite

Prabhjot Singh Bajwa, Jaya Sharma, Anurag Bhargava, Shailesh Sharma, Abhimanyu Rai Sharma, & Binu Raina. (2018). Design and development of immediate release tablets of terbutaline sulfate using 32 full factorial statistical design. Asian Pacific Journal of Health Sciences, 5(1), 47–52. https://doi.org/10.21276/apjhs.2018.5.1.11

Issue

Vol. 5 No. 1 (2018): Vol 5 | Issue 1 | January - March 2018

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.

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