Design, Development and optimization of chronomodulatedPulsincap delivery system of Valsartan

Authors

  • Abhimanyu Jagadhri, Yamuna Nagar, Haryana, India
  • Anurag Bhargava Jagadhri, Yamuna Nagar, Haryana, India
  • Prabhjot Singh Bajwa Jagadhri, Yamuna Nagar, Haryana, India
  • Binu Raina Jagadhri, Yamuna Nagar, Haryana, India
  • Pankaj sharma Jaipur National University, Jaipur, Rajasthan, India
  • Shailesh Sharma Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy,Bela, Punjab, India

DOI:

https://doi.org/10.21276/apjhs.2019.6.1.2

Keywords:

Chronothepary, Valsartan, hypertension, Pulsatile capsule, 32 Full factorial design

Abstract

Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of valsartan used for treatment of hypertension, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and guar gum. The formulation produced was targeted for the preparation of time controlling pulsatile formulation to delivery drug to site and time controlling for enhancing the bioavailability of drug, so preliminary batches were prepared to study the effect of concentration of HPMC K15M and guar gum on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software.

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Author Biographies

Abhimanyu, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, 

Anurag Bhargava, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, 

Prabhjot Singh Bajwa, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy, 

Binu Raina, Jagadhri, Yamuna Nagar, Haryana, India

Ch. Devi Lal College of Pharmacy,

Pankaj sharma, Jaipur National University, Jaipur, Rajasthan, India

School of Pharmaceutical Sciences, 

Shailesh Sharma, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy,Bela, Punjab, India

Department of Pharmaceutics,

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Published

2019-03-30

How to Cite

Abhimanyu, Anurag Bhargava, Prabhjot Singh Bajwa, Binu Raina, Pankaj sharma, & Shailesh Sharma. (2019). Design, Development and optimization of chronomodulatedPulsincap delivery system of Valsartan. Asian Pacific Journal of Health Sciences, 6(1), 10–21. https://doi.org/10.21276/apjhs.2019.6.1.2

Issue

Vol. 6 No. 1 (2019): Vol 6 | Issue 1 | January - March 2019

Section

Table of Contents

License

Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.