Antiarthritic activity of different plant extracts of Ficus religiosa stem bark in complete Freund’s adjuvantinduced arthritis in rats

Abstract

Aim: The present study was carried out to evaluate the antiarthritic activity of different plant extracts of Ficus religiosa bark on complete Freund’s adjuvant-induced arthritis in rats. Method: The different plant extracts were administered orally at a dose of 200 and 400 mg/kg. Arthritis was assessed by various parameters such as paw volume assessment, paw thickness assessment, arthritic scoring, and change in body weight on day 0, 7, 14, 21, and 28. Serum parameters such as serum glutamic oxaloacetic transaminase, serum glutamate-pyruvate transaminase, urea, and creatinine level were also estimated for assessing the antiarthritic potential of different extracts of F. religiosa. Results: The results of the current investigation concluded that methanol extract possesses a significant antiarthritic activity against adjuvant-induced arthritis model and justifying its therapeutic role in arthritic condition. Conclusion: It can be concluded from the study that the observed antiarthritic activity may be due to the presence of phytoconstituents such as flavonoids and terpenoids.