The relationship of Hepatitis C and B with diabetes of Yemeni patients

Abstract

Many of earlier reports suggest a connection between hepatitis C virus (HCV) infection and type2 diabetes (T2D). However, the results are conflicting. The aim of our study was to investigate the seroprevalence of both HCV infections and hepatitis B virus (HBV) in type 2 diabetes mellitus (DM) patients in Yemen as well as the risk of hepatitis for development diabetes mellitus.120 patients were enrolled for this study: 50 patients with T2D, 70 with chronic hepatitis(29 with HCV,36 with HBV and 5 were infections with HCV and HBV) along with 50 healthy control. Investigated hepatitis C and B patients for blood sugar, determined hepatitis B surface antigen (HBsAg) and anti-HCV in both groups, measured by chromatographic and enzyme-linked immunosorbent assay(ELSIA). We found that in T2D-patients 7 out of 50 (14%) detected with hepatitis, 5 (10 %) of 50 T2D-patients had evidence of HCV infection compared to 2 (4%) with HBV. The development diabetic mellitus among 70 hepatitis C and B patients 8 out of 70 (11.4%), 3 HBV 36 (8.3%), 4 HCV 29 (13.7%), 1 Co-infection HBV and HCV 5 (20%) compared to 1 (2%) without association in 50 control adults. The antibodies levels in T2D-patients with HCV viremia were significantly higher than those in HBV patients. HCV viremia, sex, age, family history of diabetes and tobacco use was found to be difference independent risk factors for diabetes.